The Willows Health and Recovery

The Willows Health and Recovery in Nashville, Tennessee offers ketamine treatment and Spravato for adults with treatment-resistant depression. Ketamine is administered by injection, and the FDA-approved esketamine nasal spray (Spravato) is also available, used alongside an oral antidepressant.

Ketamine binds to NMDA receptors and increases glutamate, which activates AMPA receptors and helps neurons communicate, an effect believed to improve mood and thoughts in patients with depression and anxiety. Treatment often begins with twice-weekly sessions, then tapers or shifts to maintenance doses as symptoms improve.

The practice works with each patient's treatment team to determine next steps. Other services include initial psychiatric evaluations, medication management with supportive therapy, MAT, ADHD testing, trauma-informed women's health services, and genome and laboratory testing.