Ketamine Therapy Clinics in California

Clinics across California most commonly offer ketamine therapy for treatment-resistant depression, PTSD, OCD, anxiety disorders, and certain chronic pain conditions. Those are the same conditions you will see referenced nationally, but whether ketamine is appropriate for your specific situation depends on a full clinical evaluation with a licensed provider.

IV ketamine is administered directly into a vein during an in-clinic session and is used off-label for conditions like depression and PTSD. Spravato is an FDA-approved nasal spray containing esketamine that is self-administered at the clinic under medical supervision.

The two have different clinical protocols, different cost structures, and different insurance implications. A prescribing clinician can help you sort out which one makes sense for your situation.

Los Angeles, San Diego, and San Francisco have the largest concentrations of clinics. Sacramento, Newport Beach, and Santa Monica also have several providers. Beyond those metros, clinics appear in cities across Orange County, the East Bay, the South Bay, the Central Valley, and points further north and south.

For IV ketamine, insurance coverage is uncommon, and most patients pay out of pocket. Spravato is the format most likely to be covered because it carries FDA approval, but coverage still depends on your specific plan, your diagnosis, and whether your insurer considers it medically necessary. Always call your insurance company before assuming coverage.

Sessions vary by treatment type, but in every case you will be at the clinic for the full duration. For IV infusions, you are in a reclining chair or treatment room while the medication is delivered over roughly 40 to 60 minutes, with a clinician present. Spravato sessions involve self-administering the nasal spray at the clinic and then staying for a monitored observation period afterward, typically around two hours.

A number of California clinics do publish per-infusion pricing, so you can get a general sense of what to expect before calling. That said, the total cost of a starter course depends on how many sessions your provider recommends, which varies by treatment type and individual response. Asking for an itemized estimate during your initial consultation is always a good idea.

Start by confirming which treatment format a clinic offers in your area, since not all locations carry every type. Then look at who oversees treatment, how intake and evaluation are handled, what monitoring looks like during sessions, and what happens after your starter course ends. Price transparency and a clear follow-up plan are both reasonable things to ask about upfront.

No. Every clinic listed here administers treatment on site. If you see a listing, it means you will need to show up in person for your sessions.

Yes. Ketamine is a Schedule III controlled substance under U.S. federal law and is legal for licensed clinicians to prescribe and administer off-label, including for treatment-resistant depression and other conditions.

Spravato (esketamine), the FDA-approved nasal-spray form, is dispensed only in certified healthcare settings under a federal Risk Evaluation and Mitigation Strategy (REMS) program. That applies in California as it does nationwide.

The standards for who may administer treatment are set by state regulators and by the clinicians themselves; you can look up the current licensing board for your state through the Federation of State Medical Boards directory at fsmb.org. This page is informational and not legal or medical advice. Consult a licensed medical provider before starting treatment.