Zoe Psychiatry & Sleep Medicine

Zoe Psychiatry & Sleep Medicine operates a REMS-certified Spravato suite in Richardson, Texas, serving the Dallas-Fort Worth area for adults with treatment-resistant depression. The FDA-approved esketamine nasal spray targets the NMDA receptor and increases glutamate to restore synaptic connections damaged by chronic depression, with many patients experiencing symptom reduction within 24 hours of their first treatment.

Patients self-administer the nasal spray under medical supervision in a private treatment suite, then relax for a two-hour observation period while staff monitor blood pressure. A driver is required afterward. The typical course is two sessions per week for the first month, tapering as symptoms improve.

The practice is led by double board-certified physicians Oluwole Popoola, MD, and Taiye Popoola, MD. Candidates are adults diagnosed with major depressive disorder who have tried at least two oral antidepressants and are currently taking a daily antidepressant. Spravato is also FDA-approved for acute suicidal ideation.