Michael D Lesem, MD PA

Michael D Lesem, MD PA in Houston, Texas offers Spravato for adults with treatment-resistant depression who have not responded to standard oral medications. The FDA-approved esketamine works on the glutamate neurotransmitter pathway to help restore neural connections impaired in major depressive disorder.

Treatment sessions occur on site with medical monitoring lasting approximately two hours, including blood pressure, pulse, and psychological measurements before and after. The low dose is administered via intranasal spray in two steps five minutes apart, with patients monitored by a board-certified psychiatrist.

Patients typically begin with twice-weekly sessions for the first four weeks, followed by weekly or biweekly maintenance based on clinical response. The clinic provides care in a medical setting with insurance coordination and rapid scheduling, often with same-week or next-week appointments.