Restore Brain

Restore Brain in Denton, Texas offers Spravato (esketamine), an FDA-approved nasal spray for adults with treatment-resistant depression or major depressive disorder with acute suicidal ideation. Administered in-office under medical supervision through the FDA's REMS program, it works through the glutamate system rather than the serotonin pathways of traditional antidepressants and can reduce symptoms within hours to days.

Each session involves self-administering the spray under clinical supervision, followed by a two-hour monitored observation period, with a driver required afterward. Treatment runs twice weekly for four weeks, then weekly, with extended maintenance tailored to response.

Located inside Connections Wellness Group, the Denton clinic also offers TMS therapy and serves patients across the Dallas-Fort Worth metroplex, with coordinators handling insurance prior authorization.