The Nexus Group

The Nexus Group at its Squirrel Hill office in Pittsburgh, Pennsylvania offers Spravato for adults with treatment-resistant depression and those experiencing suicidal ideation. The FDA-approved esketamine nasal spray is administered in office under the supervision of board-certified clinicians.

Treatment begins with a detailed consultation and assessment to review health history, symptoms, and goals and confirm eligibility. Patients then visit twice a week during the initial phase, self-administering the nasal spray in a comfortable clinical setting and remaining for about two hours of observation afterward.

Session frequency is reduced over time based on progress, with regular clinician check-ins to adjust the plan. Spravato works by boosting glutamate receptors and neuroplasticity, often providing relief sooner than traditional antidepressants and helping patients regain hope.