Principium Psychiatry

Principium Psychiatry's Midtown Manhattan office in New York, New York, located near Grand Central Station, offers IV ketamine therapy and Spravato (esketamine) for treatment-resistant depression, anxiety, PTSD, OCD, and related conditions. Ketamine targets the brain's glutamate system and NMDA receptors to promote neuroplasticity, often providing relief within hours or days when traditional antidepressants have not worked.

Administered by highly trained psychiatrists, treatment is tailored to each patient through IV infusion or intranasal routes, with close monitoring in a calm, medically supervised setting. The practice integrates Ketamine-Assisted Psychotherapy (KAP) where appropriate.

A physician-led interventional psychiatry practice, the Midtown office also provides TMS, psychotherapy, psychopharmacology, genetic testing, and an intensive outpatient program, with personalized, long-term care plans and ongoing follow-up.