The Pearl Institute

The Pearl Institute in Waynesville, North Carolina is a nonprofit organization offering Spravato (esketamine) and ketamine-assisted psychotherapy as part of its mission to bring innovative, trauma-informed care into mainstream practice. The institute focuses on helping community members heal from traumatic events while advancing research into psychedelic substances for therapeutic purposes.

Ketamine-assisted psychotherapy combines ketamine administration with traditional therapy in a controlled setting, where ketamine reduces psychological defenses and a trained therapist guides patients to process emotions and explore thoughts. This approach shows promise for depression, anxiety, and PTSD, especially in treatment-resistant cases.

The Waynesville clinic has been thoughtfully designed to provide a peaceful, relaxing, and comfortable space. The Pearl also offers trauma support services, wellness services, and professional events and trainings, working to reduce barriers to patient access.