The Pearl Institute
The Pearl Institute in Waynesville, North Carolina is a nonprofit organization offering Spravato (esketamine) and ketamine-assisted psychotherapy as part of its mission to bring innovative, trauma-informed care into mainstream practice. The institute focuses on helping community members heal from traumatic events while advancing research into psychedelic substances for therapeutic purposes.
Ketamine-assisted psychotherapy combines ketamine administration with traditional therapy in a controlled setting, where ketamine reduces psychological defenses and a trained therapist guides patients to process emotions and explore thoughts. This approach shows promise for depression, anxiety, and PTSD, especially in treatment-resistant cases.
The Waynesville clinic has been thoughtfully designed to provide a peaceful, relaxing, and comfortable space. The Pearl also offers trauma support services, wellness services, and professional events and trainings, working to reduce barriers to patient access.
IV Ketamine Infusions
IM Ketamine
Spravato® (esketamine)
Ketamine-Assisted Psychotherapy
Used for:
Treatment details are based on information published by the clinic, checked in August 2026.
Payment methods: CareCredit
Monday: 9:00 AM – 5:00 PM
Tuesday: 9:00 AM – 5:00 PM
Wednesday: 9:00 AM – 5:00 PM
Thursday: 9:00 AM – 5:00 PM
Friday: 9:00 AM – 5:00 PM
Saturday: Closed
Sunday: Closed
Accepts insurance
Plan participation and treatment coverage may vary by location and clinician. Confirm your benefits with the clinic.
In network with BCBS, Aetna, Aetna State Health Plan, Cigna, UHC, Medcost, and Backline Cares. Intake assessment, medical screening, prep session, and integration sessions billed through insurance where copays and deductibles apply. KAP medicine sessions are patient's responsibility and not billed through insurance.
KAP medicine sessions are 2 hours with same-day 1 hour integration session; sliding scale fees based on funding availability; intake assessment, medical screening, and prep session billed separately through insurance; integration sessions billed separately; CareCredit accepted.
Send your details to The Pearl Institute and they can reach out to you directly.
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