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    Ketamine Therapy Clinics in Mississippi

    20
    in-person clinics
    14
    cities covered

    Mississippi has a growing number of in-person ketamine therapy clinics spread across the state, from the Memphis suburbs in the north down to the Gulf Coast. This page helps you find providers by city and learn what to expect before booking an appointment.

    Ketamine therapy is used for conditions that have not responded well to standard treatments. Those conditions include treatment-resistant depression, PTSD, anxiety disorders, OCD, and certain chronic pain conditions. Whether it is the right fit for you is something only a licensed medical provider can confirm.

    The clinics listed here all administer treatment on site. You will not find at-home or telehealth ketamine options in this directory, only brick-and-mortar providers where care is delivered in person.

    Where to Find Ketamine Therapy in Mississippi

    Clinics are spread across several parts of Mississippi rather than concentrated in one major hub. The highest density of providers appears in the north and along the Gulf Coast, with Southaven, Tupelo, Madison, Oxford, and Biloxi accounting for much of the activity.

    Southaven

    3 clinics

    Southaven sits just across the Tennessee state line from Memphis, which means patients from both north Mississippi and the greater Memphis metro can reach its clinics without a long drive. Several providers here offer Spravato, the FDA-approved nasal spray administered in a monitored clinical setting. That kind of access is meaningful in a region where specialized mental health care has historically required a trek into a larger city.

    View all 3 clinics in Southaven

    Tupelo

    3 clinics

    Tupelo has long punched above its weight as a medical hub for northeast Mississippi, drawing patients from Corinth down to Columbus and the smaller towns in between. Several providers in the city offer Spravato, giving people across the region a genuine local option for treatment-resistant depression without a long haul to Jackson or Memphis. The city's established healthcare infrastructure makes coordinating care with existing providers relatively straightforward.

    View all 3 clinics in Tupelo

    Madison

    2 clinics

    Tucked just north of Jackson along the Natchez Trace corridor, Madison offers a quieter alternative to the bustle of the state capital while still being close enough for easy coordination with Jackson-area specialists. A small local presence provides Spravato here, which is welcome news for residents of Madison and the surrounding communities who prefer not to deal with city traffic for every appointment.

    View all 2 clinics in Madison

    Oxford

    2 clinics

    Oxford is best known as the home of the University of Mississippi and carries a literary and cultural energy that makes it feel larger than its population suggests. A small local presence offers Spravato for patients dealing with treatment-resistant depression, serving not just Oxford residents but also those coming in from the smaller towns of north-central Mississippi who have few other nearby options.

    View all 2 clinics in Oxford

    Biloxi

    1 clinic

    Biloxi sits at the heart of Mississippi's Gulf Coast, flanked by Gulfport to the west and Ocean Springs to the east, and it serves as a natural gathering point for medical care across the southern part of the state. A small local presence offers Spravato here, which means patients along the coast can access supervised ketamine treatment without driving north toward Jackson. For south Mississippi residents, that proximity makes a real difference.

    View all 1 clinic in Biloxi

    More Cities in Mississippi

    Ketamine and Spravato providers also operate in these Mississippi cities. Select one to see local clinics, treatment formats, and how to get started.

    How Much Ketamine Therapy Costs in Mississippi

    Published pricing is limited across Mississippi, and few clinics post their rates online. Calling a clinic directly is the most reliable way to get a real number. Cost varies based on which treatment format you choose and how many sessions are in your starter course. Spravato is the format most likely to involve insurance, though actual coverage depends on your specific plan.

    Types of Ketamine Treatment Offered in Mississippi

    Mississippi clinics lean heavily on Spravato, the FDA-approved esketamine nasal spray, which is available in more cities statewide than any other format. Other ketamine formats, like intramuscular and sublingual options, appear in a smaller number of cities, primarily Madison and Southaven. IV ketamine infusion does not currently appear among the listed providers. Every clinic in this directory is an in-person provider.

    Many clinics offer more than one format, so these figures overlap and add up to more than the total number of clinics.

    • Ketamine Infusion Therapy: 2 clinics. Available in Madison, Southaven.
    • Spravato (Esketamine): 18 clinics. Available in Biloxi, Flowood, Gulfport, Hattiesburg, and more.

    How to Choose a Ketamine Clinic in Mississippi

    Because clinics in Mississippi are spread across the state rather than clustered in one metro, your first practical question is which city is realistically reachable for multiple visits.

    • Location and travel logistics: Ketamine therapy typically requires several sessions close together at the start. A clinic you can get to consistently matters more than one that is slightly closer on a map.
    • Format offered at that location: Spravato is the most widely available treatment in Mississippi. Other ketamine formats appear in fewer cities, so confirm what a specific clinic offers before making plans.
    • Intake process and evaluation: A thorough clinic will review your medical and psychiatric history before your first session. Be cautious of any provider that skips a detailed intake.
    • Clinician credentials: Look for care supervised by a licensed physician, psychiatrist, or nurse practitioner with experience in ketamine treatment. Ask who will be present during your session.
    • Monitoring during sessions: Providers should track blood pressure, heart rate, and your overall response throughout treatment. Ask how they handle the period right after a session ends.
    • Follow-up and integration support: Some clinics offer follow-up appointments or work alongside a therapist. Knowing what happens after the initial course of treatment is a fair question to ask upfront.

    Frequently Asked Questions

    Here are answers to common questions about finding and starting ketamine therapy in Mississippi.

    What conditions are Mississippi ketamine clinics typically treating?

    Most clinics focus on patients who have not gotten adequate relief from conventional treatments. The most common conditions are treatment-resistant depression, PTSD, OCD, anxiety disorders, and certain chronic pain conditions. A licensed provider will evaluate your history to determine whether ketamine therapy makes sense for your situation.

    What is the difference between IV ketamine and Spravato?

    IV ketamine is administered through an intravenous infusion in a clinical setting and is used off-label for mental health and pain conditions. Spravato is an FDA-approved nasal spray that is self-administered under supervision at a certified clinic.

    In Mississippi, Spravato is available in many more cities than IV ketamine, which does not appear among current listed providers. The two treatments have different session formats, durations, and insurance situations, so it is worth asking a clinic which one they offer and why.

    What happens during a ketamine therapy session?

    You arrive at the clinic and are assessed before treatment begins. During the session, a clinician monitors your blood pressure, heart rate, and overall response. Spravato sessions typically last around two hours at the clinic because you are observed for a period after the dose. You will need someone to drive you home afterward.

    Which cities in Mississippi have ketamine clinics?

    Clinics are spread across the state. Southaven and Tupelo cover the north. Madison and Oxford serve the central and north-central areas. Along the Gulf Coast, providers are found in Biloxi, Gulfport, and Ocean Springs, among other cities. The full city list on this page reflects where active in-person providers are currently listed.

    Does insurance cover ketamine therapy in Mississippi?

    Spravato is the treatment most likely to have some insurance coverage, though what a given plan will pay depends on the insurer and your specific policy. IV ketamine and other formats are generally paid out of pocket. Contact both your insurance company and the clinic to clarify costs before scheduling.

    How do I find out what a clinic charges in Mississippi?

    Published pricing is sparse in this state. Most clinics do not list rates on their websites, so a direct phone call or email is the best approach. Ask about the cost per session and what the recommended starting course involves, since the total expense depends on both.

    Are there at-home or telehealth ketamine options listed here?

    No. This directory only lists in-person clinics where treatment is administered on site. If you see a provider in this directory, you are expected to visit a physical location for your sessions.

    How do I choose between clinics in different cities?

    Start with which cities are reachable for repeated visits, since the early phase of treatment often means multiple appointments in a short span of time. From there, compare the formats each clinic offers, the credentials of the supervising clinicians, and how thorough their intake process appears to be. A clinic that asks detailed questions about your history before agreeing to treat you is generally a good sign.

    Is ketamine therapy legal in Mississippi?

    Yes. Ketamine is a Schedule III controlled substance under U.S. federal law and is legal for licensed clinicians to prescribe and administer off-label, including for treatment-resistant depression and other conditions. Spravato (esketamine), the FDA-approved nasal-spray form, is dispensed only in certified healthcare settings under a federal Risk Evaluation and Mitigation Strategy (REMS) program. That applies in Mississippi as it does nationwide. The standards for who may administer treatment are set by state regulators and by the clinicians themselves; you can look up the current licensing board for your state through the Federation of State Medical Boards directory at fsmb.org. This page is informational and not legal or medical advice. Consult a licensed medical provider before starting treatment.

    This directory provides information about in-person ketamine therapy clinics in Mississippi and does not endorse any provider or offer medical advice. Ketamine therapy is used for certain conditions but is not appropriate for everyone. Always consult a licensed medical professional to determine whether treatment is right for you.