Restore Brain

Restore Brain in St. Louis, Missouri offers Spravato (esketamine), an FDA-approved nasal spray for adults with treatment-resistant depression or major depressive disorder with acute suicidal ideation. Administered in-office under medical supervision through the REMS program, it works through the glutamate system rather than the serotonin pathways of traditional antidepressants, often producing relief within hours to days.

Each visit includes self-administration under clinical supervision and a two-hour monitored observation period, with a driver required afterward. Treatment starts twice weekly for four weeks, then reduces to weekly and extended maintenance tailored to each patient.

Located in the Creve Coeur Executive Office Park, the St. Louis clinic also provides TMS therapy and serves the greater metro area, with patient coordinators managing insurance prior authorization and coverage questions.