Ketamine Therapy Clinics in Minnesota
26 in-person clinics across 18 cities in Minnesota.
Minnesota's ketamine therapy landscape is anchored by the Twin Cities metro, where a cluster of clinics spans the southern suburbs, inner-ring communities, and the city of Minneapolis itself. At the same time, access reaches well beyond the metro, with clinics serving Duluth on the North Shore and smaller communities like St. Cloud, Waite Park, and Hibbing in Greater Minnesota.
The state's providers offer a mix of treatment approaches. Spravato, the FDA-approved nasal spray form of esketamine, is the most widely available option and can be found across both urban and suburban locations. IV ketamine infusions are offered at select clinics, and a number of practices provide broader ketamine therapy programs that may include intramuscular, sublingual, or ketamine-assisted psychotherapy formats.
Whether you are based in the suburbs south of Minneapolis or in a regional city hours away, this directory is designed to help you find and compare in-person ketamine therapy providers throughout the state.
Ketamine Clinics by City in Minnesota
Burnsville
3 clinics
Duluth
2 clinics
Dundas
1 clinic
Eden Prairie
1 clinic
Edina
2 clinics
Golden Valley
1 clinic
Hibbing
1 clinic
Lake Elmo
1 clinic
Maple Grove
3 clinics
Minneapolis
3 clinics
Minnetonka
1 clinic
Oakdale
1 clinic
Plymouth
1 clinic
St. Cloud
1 clinic
St Louis Park
1 clinic
St. Paul
1 clinic
Vadnais Heights
1 clinic
Waite Park
1 clinic
Where to Find Ketamine Therapy in Minnesota
Burnsville
3 clinicsBurnsville sits in Dakota County just south of the Twin Cities core and serves as a convenient access point for residents throughout the southern metro. Clinics here offer both Spravato and broader ketamine therapy programs, giving patients a choice of treatment formats without needing to travel into Minneapolis proper.
Maple Grove
3 clinicsMaple Grove anchors the northwest suburban corridor and draws patients from communities across Hennepin and Anoka counties. Providers in this area offer Spravato as well as ketamine therapy programs, making it one of the more accessible suburban hubs for treatment in the metro.
- The Modern Experience Clinic
Maple Grove
Ketamine TherapySpravato (Esketamine)TMSMedication Management
Minneapolis
3 clinicsAs the state's largest city, Minneapolis naturally draws a concentration of ketamine therapy providers offering multiple modalities, including Spravato and broader ketamine therapy approaches. Its central location and transit connections make it a practical destination for patients arriving from surrounding neighborhoods and inner suburbs.
Duluth
2 clinicsDuluth is the most significant access point for ketamine therapy in northeastern Minnesota, serving a wide geographic catchment that includes communities along Lake Superior and well into the Iron Range region. Clinics here offer Spravato and ketamine therapy programs, providing meaningful options for patients who would otherwise face long drives to the Twin Cities.
Edina
2 clinicsEdina is a well-served inner-ring suburb on the southwestern edge of Minneapolis with clinics offering both Spravato and broader ketamine therapy formats. Its compact geography and proximity to the Minneapolis core make it a practical alternative for patients seeking treatment just outside the urban center.
How Much Ketamine Therapy Costs in Minnesota
Across 6 clinics that publish rates, in-person sessions run $150 to $800 per session. A standard starter course of six sessions works out to roughly $1,800 based on the median published price. Many clinics offer package or self-pay options, so confirm current pricing directly with the provider.
Several Minnesota clinics publish their per-infusion or per-session pricing, so some price comparison is possible before you make contact. A starter course of infusions generally represents a meaningful out-of-pocket commitment, and total costs vary depending on the number of sessions in a protocol, the clinic's setting and amenities, and whether any complementary services such as integration therapy or medical consultations are bundled in. Spravato is the one format that may qualify for insurance coverage under certain circumstances, since it carries FDA approval for specific diagnoses. IV ketamine and other modalities are used off-label and are almost universally self-pay. Clinics vary in whether they offer payment plans, so it is worth asking directly when you inquire.
Types of Ketamine Treatment Offered in Minnesota
Minnesota clinics work with three main treatment formats. Spravato, the FDA-approved esketamine nasal spray, is administered in a clinical setting with supervised observation and is offered at the largest number of locations across the state, including multiple Twin Cities suburbs such as Burnsville, Edina, Maple Grove, Minnetonka, Plymouth, Oakdale, and Golden Valley, as well as Duluth, St. Cloud, Waite Park, Lake Elmo, St. Paul, and St. Louis Park. IV ketamine infusions, which are used off-label, are available at clinics in Hibbing and St. Louis Park. Broader ketamine therapy programs, which may include intramuscular administration, sublingual formats, or ketamine-assisted psychotherapy, are offered at clinics in Minneapolis, Burnsville, Duluth, Edina, Maple Grove, Golden Valley, Eden Prairie, Vadnais Heights, Dundas, St. Cloud, and Waite Park. Every clinic listed in this directory provides treatment on site, and no at-home or telehealth ketamine services are included.
- IV Ketamine Infusion offered at 2 clinics, including Hibbing, St Louis Park.
- Spravato (Esketamine) offered at 18 clinics, including Burnsville, Duluth, Edina, Golden Valley.
- Ketamine Therapy offered at 14 clinics, including Burnsville, Duluth, Dundas, Eden Prairie.
How to Choose a Ketamine Clinic in Minnesota
Minnesota's clinic distribution means your first practical question is geography. If you are in the Twin Cities metro, you likely have several options within a reasonable drive, so you can compare modalities, published pricing, and clinic philosophy. If you are in a regional area such as Duluth, St. Cloud, or the Iron Range, your local choices may be more limited, and it is worth confirming which treatment format a nearby clinic offers before making an inquiry. Once you have a short list, consider these factors: which modality your clinician recommends based on your diagnosis and history; whether the clinic publishes pricing or will share it transparently on request; what the protocol looks like in terms of number of sessions and follow-up support; whether integration counseling or psychotherapy is part of the program or available as an add-on; and how the clinic handles the initial medical evaluation. Finally, check whether a clinic accepts any insurance, particularly if you are considering Spravato, and ask specifically about payment plan options if upfront cost is a concern.
Ketamine Therapy in Minnesota: Frequently Asked Questions
What conditions is ketamine therapy used for in Minnesota clinics?
Clinics in Minnesota commonly work with patients seeking care for treatment-resistant depression, major depressive disorder, anxiety disorders, PTSD, OCD, and chronic pain conditions. Some clinics also see patients dealing with bipolar depression. A licensed medical provider at the clinic will evaluate whether ketamine therapy is appropriate for your specific situation.
What is the difference between IV ketamine and Spravato?
IV ketamine delivers the medication directly into the bloodstream through an intravenous line, allowing for precise dosing during a supervised infusion session. Spravato is an FDA-approved nasal spray containing esketamine, a related compound, that is self-administered in a clinic under observation. IV ketamine is used off-label for most psychiatric indications, while Spravato carries FDA approval for specific diagnoses. Availability differs across Minnesota: Spravato is offered at many more locations statewide, while IV infusions are available at fewer clinics.
What does a typical ketamine therapy visit look like?
Your first appointment usually involves a medical and psychiatric intake evaluation before any treatment begins. Once you are approved for treatment, sessions take place in a clinical room where staff monitor your vital signs and comfort throughout. Depending on the format, a session may last anywhere from about 45 minutes to a few hours, and you will need a driver to take you home afterward. Many protocols involve a series of sessions over several weeks rather than a single visit.
Does insurance cover ketamine therapy in Minnesota?
Spravato may be covered by insurance for qualifying patients with a matching diagnosis, because it holds FDA approval. IV ketamine and other modalities are used off-label and are almost always paid out of pocket. Coverage details depend entirely on your specific plan, so contact your insurer directly and ask the clinic whether they assist with prior authorization or superbills for reimbursement.
How much does a course of ketamine therapy cost?
Some Minnesota clinics publish per-session pricing, which makes early comparison easier than in many states. A starter course of infusions represents a meaningful investment, and total costs depend on the number of sessions your provider recommends, the clinic's setting, and whether additional services are included. Ask each clinic you contact for a full breakdown of what is included in their pricing.
Which cities in Minnesota have ketamine therapy clinics?
Clinics are concentrated in the Twin Cities metro, with providers in Minneapolis, Burnsville, Maple Grove, Edina, St. Louis Park, Golden Valley, Minnetonka, Plymouth, Oakdale, Lake Elmo, Eden Prairie, Vadnais Heights, and St. Paul, among others. Outside the metro, Duluth is the main access point in the northeast, and St. Cloud and Waite Park serve the central part of the state. Hibbing and Dundas also have providers, extending access into smaller communities.
Is this directory limited to in-person clinics?
Yes. Every provider listed here administers treatment at a physical clinic location. This directory does not include at-home ketamine services or telehealth-only programs.
What should I ask a clinic before booking an appointment?
Start by confirming which treatment modality or modalities the clinic offers and whether you are a candidate for the recommended format. Ask what the intake evaluation process involves, how many sessions are typical for your situation, what the total cost would be, whether payment plans are available, and how the clinic handles follow-up care after your initial course of treatment. If you have insurance, ask whether the clinic can assist with any reimbursement documentation.
Is there a difference between ketamine therapy in the Twin Cities suburbs versus regional cities like Duluth?
Patients in the Twin Cities metro generally have more clinics to choose from and can compare modalities, pricing, and program structures more easily. In regional cities like Duluth, fewer clinics operate, but they often serve a broad geographic area and may have intake processes designed for patients traveling from a distance. If you are outside the metro, it is worth calling ahead to understand scheduling flexibility and whether multi-day arrangements can be made.
Can ketamine therapy be combined with other mental health treatment?
Many clinics encourage patients to maintain a relationship with an existing therapist or psychiatrist alongside ketamine treatment. Some Minnesota providers offer ketamine-assisted psychotherapy as part of their program, pairing the medication session with structured therapeutic support. Ask any clinic you consider whether they integrate counseling into their protocol or can coordinate with your current mental health providers.
Is ketamine therapy legal in Minnesota?
Yes. Ketamine is a Schedule III controlled substance under U.S. federal law and is legal for licensed clinicians to prescribe and administer off-label, including for treatment-resistant depression and other conditions. Spravato (esketamine), the FDA-approved nasal-spray form, is dispensed only in certified healthcare settings under a federal Risk Evaluation and Mitigation Strategy (REMS) program. That applies in Minnesota as it does nationwide. The standards for who may administer treatment are set by state regulators and by the clinicians themselves; you can look up the current licensing board for your state through the Federation of State Medical Boards directory at fsmb.org. This page is informational and not legal or medical advice. Consult a licensed medical provider before starting treatment.
This directory provides information about in-person ketamine therapy clinics in Minnesota and does not endorse any provider or offer medical advice. Ketamine therapy is used for certain conditions but is not appropriate for everyone. Always consult a licensed medical professional to determine whether treatment is right for you.