Cortex Behavioral Health

Cortex Behavioral Health in Portland, Maine offers Spravato (esketamine), an FDA-approved treatment for treatment-resistant depression, which affects roughly 10 to 30 percent of patients with major depressive disorder who have not responded well to multiple antidepressants. Esketamine works in a completely different way than conventional depression medications.

The practice is certified in the SPRAVATO REMS program and has been treating patients with esketamine for years, giving it significant experience with the treatment. Three private treatment rooms allow patients to receive care in comfort, with the special monitoring this medication requires.

Cortex specializes in co-occurring disorders and addiction, offering Spravato alongside psychiatric services, individual therapy including CBT and DBT, and addiction treatment with injectable medications like Sublocade, Brixadi, and Vivitrol. Esketamine referrals can be faxed from a PCP or psychiatric provider.