Ketamine Therapy Clinics in Massachusetts
78 in-person clinics across 49 cities in Massachusetts.
Massachusetts has developed one of the more geographically diverse ketamine therapy landscapes in New England. While Boston and its surrounding communities anchor the highest concentration of providers, clinics have taken hold across the state from the South Shore and Cape Cod to the Pioneer Valley and the Berkshires, giving residents in many parts of the Commonwealth reasonable access to care.
The mix of available treatment approaches reflects that breadth. IV ketamine infusions are offered at a solid cluster of clinics concentrated in Greater Boston and the Worcester area. Spravato, the FDA-approved nasal-spray form of esketamine, has the widest geographic footprint of any modality here, with providers spread across suburbs, mid-sized cities, and even smaller towns that would not typically show up on these maps. Ketamine-assisted psychotherapy and other integrative approaches are also available at select clinics, particularly in the Boston metro, the North Shore, and into western Massachusetts.
Several clinics do publish their per-infusion and starter-course pricing, which gives prospective patients a useful starting point for financial planning. Self-pay remains the norm for most treatment types, though Spravato carries a different insurance dynamic worth discussing directly with any clinic you contact.
Ketamine Clinics by City in Massachusetts
Acton
2 clinics
Attleboro
1 clinic
Belmont
1 clinic
Beverly
2 clinics
Boston
6 clinics
Braintree
1 clinic
Brookline
3 clinics
Cambridge
3 clinics
Charlestown
1 clinic
Cohasset
1 clinic
Danvers
1 clinic
Dartmouth
1 clinic
Dudley
1 clinic
East Falmouth
1 clinic
Framingham
2 clinics
Franklin
1 clinic
Greenfield
1 clinic
Hanover
1 clinic
Hyannis
1 clinic
Leominster
2 clinics
Lexington
3 clinics
Lowell
1 clinic
Milford
1 clinic
Natick
1 clinic
Needham
1 clinic
Newton
3 clinics
Northampton
2 clinics
North Andover
3 clinics
Northborough
1 clinic
North Chelmsford
1 clinic
Norwood
1 clinic
Peabody
1 clinic
Pembroke
1 clinic
Pittsfield
1 clinic
Plymouth
1 clinic
Randolph
1 clinic
Springfield
1 clinic
Stoneham
1 clinic
Sturbridge
1 clinic
Tewksbury
1 clinic
Walpole
1 clinic
Wellesley
2 clinics
Westborough
1 clinic
West Boylston
1 clinic
West Springfield
2 clinics
Weymouth
2 clinics
Whitinsville
1 clinic
Woburn
3 clinics
Worcester
5 clinics
Where to Find Ketamine Therapy in Massachusetts
Boston
6 clinicsBoston is the clear hub of ketamine care in Massachusetts, bringing together all three major treatment modalities within a single city. Patients here can access IV infusion clinics, Spravato-certified providers, and practices offering integrative or psychotherapy-assisted ketamine, making it the most option-rich location in the state for those weighing different approaches.
- Whitley Wellness
Boston
IV Ketamine InfusionKetamine TherapySpravato (Esketamine)TMSPsychiatryMedication Management
Worcester
5 clinicsWorcester functions as the state's secondary hub, with both IV ketamine infusion and Spravato available in the city itself. Its central location in the Commonwealth makes it a practical destination for patients who live within an hour's drive but outside the Boston metro corridor.
Brookline
3 clinicsBrookline, sitting just west of Boston, hosts providers offering IV infusions, Spravato, and integrative ketamine therapy, giving it a concentrated range of options for an inner suburb. Its proximity to major medical institutions in the Boston area is reflected in the clinical depth of its provider mix.
Cambridge
3 clinicsCambridge's ketamine clinic presence leans toward Spravato and integrative therapy approaches, fitting the city's strong behavioral health culture. Patients looking for a treatment experience that incorporates therapeutic support alongside the medical protocol will find relevant providers to evaluate here.
Lexington
3 clinicsLexington stands out among suburban Massachusetts towns by offering all three modalities: IV infusions, Spravato, and broader ketamine therapy services. That range in a single mid-sized suburb makes it a notable destination for residents of the northwest metro area who prefer not to travel into Boston proper.
- LifeStance Health
Lexington
IV Ketamine InfusionSpravato (Esketamine)PsychiatryMedication ManagementTherapy
How Much Ketamine Therapy Costs in Massachusetts
Across 9 clinics that publish rates, in-person sessions run $500 to $750 per session. A standard starter course of six sessions works out to roughly $3,300 based on the median published price. Many clinics offer package or self-pay options, so confirm current pricing directly with the provider.
Published pricing exists for a meaningful number of clinics in Massachusetts, which is more transparency than you find in many states. A starter course of IV infusions, typically a series of sessions scheduled over a few weeks, is the most commonly priced package you will encounter, and several providers publish those figures openly. Individual session pricing varies depending on the treatment type, session length, any integrated therapy components, and the clinical setting. IV infusion costs tend to be higher per session than other modalities due to staffing and monitoring requirements. Spravato operates under a different financial structure since it is FDA-approved and may be billed to insurance in some cases, but out-of-pocket exposure can still be significant depending on your plan. Integrative or psychotherapy-assisted ketamine often bundles the medicine with a therapist's time, which affects the overall cost calculation. Always ask each clinic for a full breakdown of what a complete course of treatment will cost before committing.
Types of Ketamine Treatment Offered in Massachusetts
Three distinct treatment approaches show up consistently across Massachusetts clinics. IV ketamine infusion is the most established medically and is available at clinics concentrated in Boston, Brookline, Lexington, Worcester, and a ring of suburbs including Newton, Wellesley, Stoneham, and Plymouth, among others. Spravato, the esketamine nasal spray administered under clinical supervision through a federally mandated program, has by far the widest reach across the state, with providers in dozens of communities ranging from Lowell and Beverly on the North Shore to Pittsfield in the Berkshires and Hyannis on the Cape. Integrative ketamine approaches, which may include intramuscular administration, sublingual formulations, or ketamine-assisted psychotherapy, are available through select providers in Boston, Cambridge, Brookline, Lexington, Northampton, Springfield, and a number of other locations across both the eastern and western parts of the state. This directory covers in-person clinics only, meaning every provider listed administers treatment on site under direct clinical supervision.
- IV Ketamine Infusion offered at 13 clinics, including Boston, Brookline, Franklin, Leominster.
- Spravato (Esketamine) offered at 55 clinics, including Acton, Attleboro, Beverly, Boston.
- Ketamine Therapy offered at 39 clinics, including Acton, Belmont, Beverly, Boston.
How to Choose a Ketamine Clinic in Massachusetts
Massachusetts gives patients more geographic options than most states, but the right clinic still depends on several practical factors worth thinking through before you make contact. Start with location and logistics: a multi-session infusion protocol requires repeated visits, so proximity or ease of transit matters, especially for those in areas like the South Shore, the Cape, or western Massachusetts where fewer IV options exist locally. Next, match the modality to your clinical situation. IV infusions, Spravato, and integrative therapy differ in how they are administered, how long sessions take, and what medical oversight is required. Your referring provider or psychiatrist is the right person to help guide that choice. If published pricing is available from a clinic, use it to build a realistic budget for a full course of treatment rather than a single session. For those considering Spravato specifically, ask the clinic directly about insurance verification before your first appointment. Finally, look at the clinical team: whether a board-certified anesthesiologist, psychiatrist, or licensed therapist leads the treatment matters for both safety and the overall quality of care you receive.
Ketamine Therapy in Massachusetts: Frequently Asked Questions
What conditions is ketamine therapy used for in Massachusetts clinics?
Clinics in Massachusetts most commonly offer ketamine therapy for treatment-resistant depression, anxiety disorders, PTSD, OCD, and certain chronic pain conditions. Some integrative practices also work with patients on grief, trauma, and other mental health challenges. Ketamine is not a cure for any condition; it is a treatment option, and whether it is appropriate for you is a decision to make with a licensed medical provider who knows your history.
What is the difference between IV ketamine infusions and Spravato?
IV ketamine is administered intravenously in a clinical setting, with the dose and rate controlled by the treating provider. Spravato is a nasal spray containing esketamine, the S-enantiomer of ketamine, and is FDA-approved specifically for treatment-resistant depression and major depressive disorder with suicidal ideation. Spravato must be administered and monitored in a certified healthcare setting under a federal REMS program. IV ketamine is prescribed off-label. Both require in-person clinical supervision; neither can be done at home.
What does a typical ketamine infusion visit look like?
Before your first session you will generally complete a medical intake and screening to confirm you are a candidate. On treatment days you will arrive at the clinic, receive the infusion through an IV line over roughly 40 to 60 minutes depending on the protocol, and remain monitored during a recovery period afterward. You will not be able to drive yourself home. A typical initial course involves multiple sessions scheduled over a few weeks, followed by maintenance appointments as needed.
How much does ketamine therapy cost in Massachusetts?
Several Massachusetts clinics publish their pricing, which is helpful for planning. A starter series of IV infusions is priced meaningfully by some providers, giving you a real number to work with. Individual session costs vary by modality, session length, and whether therapy is bundled in. Spravato may be eligible for insurance coverage in some cases, but out-of-pocket costs can still be substantial. Always request a full cost breakdown from any clinic before scheduling.
Does insurance cover ketamine therapy?
Most insurance plans do not cover IV ketamine infusions because they are administered off-label. Spravato has better insurance standing as an FDA-approved medication, and some plans do cover it, though prior authorization requirements and coverage limits vary considerably. Most patients should plan for significant self-pay costs regardless of modality, and it is worth asking each clinic about their billing and verification process before your first visit.
Which cities in Massachusetts have ketamine clinics?
Boston has the broadest concentration of providers, but clinics are spread widely across the state. IV infusion clinics operate in the Greater Boston area as well as Worcester, Lexington, Newton, Wellesley, Plymouth, and other communities. Spravato providers are found across an especially wide geography, from Lowell, Beverly, and Danvers in the north to Springfield, Pittsfield, and Northampton in the west, and Hyannis and East Falmouth on the Cape. Integrative therapy approaches are available in Boston, Cambridge, Brookline, Northampton, Springfield, and numerous other locations.
Can I receive ketamine treatment at home or via telehealth?
This directory lists in-person clinics only. All providers listed administer treatment on site under direct clinical supervision. Ketamine treatment requires medical monitoring during and after sessions, and that is not something this directory addresses outside of a supervised clinical environment.
How do I choose between the different modalities available in Massachusetts?
The choice between IV infusion, Spravato, and integrative or psychotherapy-assisted approaches depends on your diagnosis, medical history, treatment goals, and practical factors like cost and clinic location. A psychiatrist or your current mental health provider is the best person to guide that decision. If you are specifically exploring Spravato, make sure the clinic is a certified treatment center. If you want a therapy component integrated into your sessions, look for practices that employ licensed therapists alongside their medical staff.
What should I ask a clinic before booking an appointment?
Ask about the credentials of the supervising clinician, whether they conduct a full medical and psychiatric intake before treatment, what the session and monitoring protocol looks like, how they handle adverse reactions, and what follow-up care looks like after a starter course. Also ask for a clear breakdown of the total cost of a complete course of treatment, not just a single session price, and clarify what happens if you need additional sessions beyond the initial series.
Is ketamine therapy new, or is it well-established?
Ketamine has been used as an anesthetic in medical settings for decades. Its use for mood disorders and chronic pain is more recent but is supported by a growing body of clinical research. Spravato received FDA approval in 2019 for treatment-resistant depression. Off-label IV and other forms of ketamine therapy have been administered in clinical settings across the country, including in Massachusetts, for a number of years. Consulting with a board-certified psychiatrist or anesthesiologist is the right way to evaluate whether the evidence and the approach fit your specific situation.
Is ketamine therapy legal in Massachusetts?
Yes. Ketamine is a Schedule III controlled substance under U.S. federal law and is legal for licensed clinicians to prescribe and administer off-label, including for treatment-resistant depression and other conditions. Spravato (esketamine), the FDA-approved nasal-spray form, is dispensed only in certified healthcare settings under a federal Risk Evaluation and Mitigation Strategy (REMS) program. That applies in Massachusetts as it does nationwide. The standards for who may administer treatment are set by state regulators and by the clinicians themselves; you can look up the current licensing board for your state through the Federation of State Medical Boards directory at fsmb.org. This page is informational and not legal or medical advice. Consult a licensed medical provider before starting treatment.
This directory provides information about in-person ketamine therapy clinics in Massachusetts and does not endorse any provider or offer medical advice. Ketamine therapy is used for certain conditions but is not appropriate for everyone. Always consult a licensed medical professional to determine whether treatment is right for you.