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    Ketamine Therapy Clinics in Massachusetts

    81
    in-person clinics
    52
    cities covered
    $500+
    published per session

    Massachusetts has a well-developed ketamine therapy scene, spread across Boston and its suburbs as well as cities farther out like Worcester, Springfield, and Northampton. This page is a directory of in-person clinics only, so every listing you see involves showing up at a physical location for treatment.

    Ketamine therapy is used for a range of conditions, most commonly treatment-resistant depression, PTSD, anxiety disorders, OCD, and certain chronic pain conditions. Whether it makes sense for you personally is a question for a licensed medical provider who can review your full history.

    Below you will find clinics organized by city, along with cost context, treatment formats, and tips on what to ask before booking. The goal is to give you enough information to start a real conversation with a clinic.

    Where to Find Ketamine Therapy in Massachusetts

    Clinics are scattered across the state, though the heaviest concentration sits in and around Boston, Brookline, Cambridge, and Lexington. Worcester serves as the main hub for central Massachusetts, with additional locations reaching from the South Shore to the Pioneer Valley.

    Boston

    6 clinics

    Boston's deep concentration of hospitals, teaching institutions, and specialty practices makes it one of the busier areas in the state for ketamine treatment. Patients here can find providers offering IV infusion and Spravato across a range of clinical settings, from standalone wellness practices to medically oriented clinics affiliated with the city's broader healthcare community. Whether you are coming from the South Shore, the North Shore, or the suburbs west of the city, Boston is often the hub people turn to when they want access to experienced, well-credentialed care.

    View all 6 clinics in Boston

    Worcester

    5 clinics

    Sitting at the center of the state, Worcester is the natural hub for patients across central Massachusetts who do not want to make the hour-long drive east to Boston. Several providers in the city offer both IV infusion and Spravato, giving people from places like Fitchburg, Framingham, and the Quabbin region a realistic local option. Worcester's growing medical sector, anchored by UMass Chan Medical School, has helped build a clinical environment where mental health treatment is taken seriously.

    View all 5 clinics in Worcester

    Brookline

    3 clinics

    Brookline occupies a distinctive spot just over the Boston city line, close enough to draw on the metro area's medical talent while feeling more like a neighborhood than a downtown medical district. Patients here have access to IV infusion, Spravato, and IM ketamine, a broader set of options than many comparable suburban communities. For people coming from Newton, Chestnut Hill, or the Longwood Medical Area corridor, Brookline offers genuine convenience without the parking and pace of central Boston.

    View all 3 clinics in Brookline

    Cambridge

    3 clinics

    Cambridge brings a distinctly research-informed sensibility to mental health care, shaped by its proximity to Harvard, MIT, and the network of affiliated hospitals along the Charles River. Providers here offer Spravato, IM ketamine, and oral or sublingual ketamine, reflecting a clinical culture that tends to take a thoughtful, evidence-oriented approach to treatment options. Patients from Somerville, Medford, and the northern suburbs often find Cambridge to be the most accessible point of entry to specialized psychiatric ketamine care in Greater Boston.

    View all 3 clinics in Cambridge

    Lexington

    3 clinics

    Lexington is a well-connected suburb about twelve miles northwest of Boston, positioned along Route 2 in a corridor that draws patients from Bedford, Concord, Burlington, and the broader MetroWest region. Several providers in the area offer IV infusion and Spravato, making it a practical choice for people who want quality care without committing to a trip into the city. The town's strong concentration of healthcare professionals in the surrounding communities has helped support a thoughtful local treatment environment.

    View all 3 clinics in Lexington

    More Cities in Massachusetts

    Ketamine and Spravato providers also operate in these Massachusetts cities. Select one to see local clinics, treatment formats, and how to get started.

    Acton

    2 clinics

    Attleboro

    1 clinic

    Belmont

    1 clinic

    Beverly

    2 clinics

    Braintree

    1 clinic

    Charlestown

    1 clinic

    Cohasset

    1 clinic

    Danvers

    1 clinic

    Dartmouth

    1 clinic

    Dudley

    1 clinic

    East Falmouth

    1 clinic

    Framingham

    2 clinics

    Franklin

    1 clinic

    Greenfield

    1 clinic

    Hanover

    1 clinic

    Hyannis

    1 clinic

    Leominster

    2 clinics

    Lowell

    1 clinic

    Mansfield

    1 clinic

    Milford

    1 clinic

    Natick

    1 clinic

    Needham

    1 clinic

    Newton

    3 clinics

    Northampton

    2 clinics

    North Andover

    3 clinics

    Northborough

    1 clinic

    North Chelmsford

    1 clinic

    Norwood

    1 clinic

    Peabody

    1 clinic

    Pembroke

    1 clinic

    Pittsfield

    1 clinic

    Plainville

    1 clinic

    Plymouth

    1 clinic

    Randolph

    1 clinic

    Somerset

    1 clinic

    Springfield

    1 clinic

    Stoneham

    1 clinic

    Sturbridge

    1 clinic

    Tewksbury

    1 clinic

    Walpole

    1 clinic

    Wellesley

    2 clinics

    Westborough

    1 clinic

    West Boylston

    1 clinic

    West Springfield

    2 clinics

    Weymouth

    2 clinics

    Whitinsville

    1 clinic

    Woburn

    3 clinics

    How Much Ketamine Therapy Costs in Massachusetts

    Average ketamine infusion cost in Massachusetts: approximately $560 per session (based on 9 clinics with published pricing).

    Several clinics in Massachusetts publish their per-infusion rates, so price comparisons are more practical here than in states where clinics rarely share figures. That said, final costs depend heavily on which treatment type you choose and how many sessions make up your starter course. Self-pay is the norm for IV infusion, while Spravato, the FDA-approved nasal spray, is the format most likely to be covered by insurance, though what any plan actually pays varies considerably.

    Types of Ketamine Treatment Offered in Massachusetts

    IV ketamine infusion is available across a solid stretch of Massachusetts communities, from Greater Boston suburbs out to Worcester and beyond, though the widest geographic reach belongs to Spravato, which turns up in towns well outside the main metros. Other formats, like intramuscular injection, sublingual ketamine, and ketamine-assisted psychotherapy, are concentrated in the Boston area and a handful of outpost cities. Every clinic in this directory administers treatment in person at a physical location.

    Many clinics offer more than one format, so these figures overlap and add up to more than the total number of clinics.

    • Ketamine Infusion Therapy: 21 clinics. Available in Boston, Brookline, Charlestown, Cohasset, and more.
    • Spravato (Esketamine): 66 clinics. Available in Acton, Attleboro, Beverly, Boston, and more.
    • Other Ketamine Formats: 10 clinics. Available in Belmont, Brookline, Cambridge, Cohasset, and more.Other ways ketamine is given, like intramuscular injection or oral and sublingual dosing.

    Separately, 6 clinics in Massachusetts offer Ketamine-Assisted Psychotherapy, which pairs ketamine with guided therapy sessions rather than a delivery method of its own. Available in Belmont, Beverly, Brookline, Cambridge, and more.

    How to Choose a Ketamine Clinic in Massachusetts

    Massachusetts clinics range from busy urban practices in Boston to smaller standalone offices in towns like Lexington or Plymouth, so the right choice depends on both logistics and clinical fit.

    • Format and location: IV infusion is available in fewer cities than Spravato, so if you live outside Greater Boston or Worcester, check which treatment types are actually offered near you before anything else.
    • Initial evaluation: Every reputable clinic will require a medical or psychiatric intake before your first session. Ask whether this is done in person or remotely, and who conducts it.
    • Clinician credentials: Find out whether a physician, nurse practitioner, or anesthesiologist will be overseeing your care. The level of medical oversight matters, especially for IV treatments.
    • Monitoring during sessions: Ask what is tracked during treatment, specifically blood pressure, heart rate, and oxygen levels. This tells you a lot about how seriously a clinic approaches safety.
    • Pricing and payment options: Some clinics publish package pricing; others quote per-session rates. Ask upfront whether they offer payment plans, and if you are interested in Spravato, ask whether they will verify your insurance before your first visit.
    • Follow-up and integration: A single course of sessions is rarely the whole picture. Ask what the clinic recommends after the initial series and whether they coordinate with your existing mental health providers.

    Frequently Asked Questions

    Here are answers to common questions about finding and starting ketamine therapy in Massachusetts.

    What conditions is ketamine therapy used for in Massachusetts clinics?

    Most clinics in Massachusetts see patients for treatment-resistant depression, PTSD, and anxiety disorders. OCD and certain chronic pain conditions also appear on the accepted diagnoses lists at many practices.

    That said, whether ketamine therapy is appropriate depends on your specific situation. A licensed medical provider at the clinic will review your history and decide whether to move forward.

    How is IV ketamine different from Spravato?

    IV ketamine is delivered through an intravenous line over a controlled session, typically lasting 40 to 60 minutes. It is used off-label, which means it is not FDA-approved for psychiatric conditions but is widely administered by qualified clinicians for that purpose. Spravato is an FDA-approved nasal spray form of esketamine, administered in a clinic setting with a required observation period afterward. The two treatments have different dosing protocols, costs, and insurance situations.

    Which cities in Massachusetts have the most clinic options?

    Boston, Brookline, Cambridge, Lexington, and Worcester have the strongest concentration of clinics. Spravato is available across a much wider set of towns. It reaches places like Springfield, Northampton, Pittsfield, and communities on the South Shore and Cape Cod.

    Does insurance cover ketamine therapy in Massachusetts?

    Coverage is limited for most formats. IV ketamine is almost always self-pay. Spravato has the best chance of insurance reimbursement because it carries FDA approval, but whether your specific plan covers it depends on your insurer, your diagnosis, and whether you meet prior-authorization requirements.

    What does a typical ketamine session involve?

    For IV infusion, you arrive at the clinic, go through a brief check-in, and receive the infusion while reclining in a monitored setting. For Spravato, a nurse or clinician administers the nasal spray and then observes you for about two hours before you are cleared to leave. Either way, you cannot drive yourself home after a session, so plan for a ride.

    How much does ketamine therapy cost in Massachusetts?

    Several Massachusetts clinics publish their pricing, which makes it easier to compare than in many states. The cost of a starter course of infusions generally falls in a range that reflects both the number of sessions and the type of treatment chosen. Self-pay packages are common, and some clinics offer financing. Call the specific clinic to get an exact quote for your situation.

    Do I need a referral to visit a ketamine clinic?

    Most clinics accept self-referrals, which means you can reach out directly without a referral from another provider. However, many will want records from your current psychiatrist or prescriber to confirm your diagnosis and treatment history. Bringing those records speeds up the intake process.

    Are there clinics outside the Boston metro area?

    Yes. While Greater Boston has the densest cluster of options, clinics are spread across Worcester, Springfield, Northampton, Pittsfield, Plymouth, and other communities. Spravato in particular is offered in towns across the South Shore, the North Shore, and out into western Massachusetts.

    Does this directory list at-home or telehealth ketamine services?

    No. Every listing here is an in-person clinic where treatment is administered on site. At-home or telehealth ketamine services are not covered in this directory.

    Is ketamine therapy legal in Massachusetts?

    Yes. Ketamine is a Schedule III controlled substance under U.S. federal law and is legal for licensed clinicians to prescribe and administer off-label, including for treatment-resistant depression and other conditions. Spravato (esketamine), the FDA-approved nasal-spray form, is dispensed only in certified healthcare settings under a federal Risk Evaluation and Mitigation Strategy (REMS) program. That applies in Massachusetts as it does nationwide. The standards for who may administer treatment are set by state regulators and by the clinicians themselves; you can look up the current licensing board for your state through the Federation of State Medical Boards directory at fsmb.org. This page is informational and not legal or medical advice. Consult a licensed medical provider before starting treatment.

    This directory provides information about in-person ketamine therapy clinics in Massachusetts and does not endorse any provider or offer medical advice. Ketamine therapy is used for certain conditions but is not appropriate for everyone. Always consult a licensed medical professional to determine whether treatment is right for you.