Southern Illinois Associates

Southern Illinois Associates in Maryville, Illinois offers both ketamine and Spravato for adults 18 and older with treatment-resistant depression, bipolar depression, PTSD, and chronic suicidal ideation. Rapid-acting IV and IM ketamine therapy is delivered by board-certified psychiatry with monitoring throughout every session, providing relief that does not wait weeks.

The practice also operates a REMS-certified Spravato site, offering the FDA-approved esketamine nasal spray that works on the same glutamate system by a different route, often covered by insurance with same-day onset.

Serving Madison County and the Metro East since 2004, the clinic also provides TMS therapy, the SAINT protocol, diagnostic services, and a walk-in clinic, with same-day starts available where clinically appropriate. Walk-ins are welcome Monday through Friday.