Southern Illinois Associates
Southern Illinois Associates in Maryville, Illinois offers both ketamine and Spravato for adults 18 and older with treatment-resistant depression, bipolar depression, PTSD, and chronic suicidal ideation. Rapid-acting IV and IM ketamine therapy is delivered by board-certified psychiatry with monitoring throughout every session, providing relief that does not wait weeks.
The practice also operates a REMS-certified Spravato site, offering the FDA-approved esketamine nasal spray that works on the same glutamate system by a different route, often covered by insurance with same-day onset.
Serving Madison County and the Metro East since 2004, the clinic also provides TMS therapy, the SAINT protocol, diagnostic services, and a walk-in clinic, with same-day starts available where clinically appropriate. Walk-ins are welcome Monday through Friday.
IM Ketamine
Spravato® (esketamine)
Treatment details are based on information published by the clinic, checked in August 2026.
Monday-Friday: 8:00am-5:00pm
Contact clinic for pricing.
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