Ketamine Therapy Clinics in Colorado

Clinics in Colorado most commonly work with patients who have treatment-resistant depression, which means their symptoms have not improved with standard antidepressants. Providers also work with patients who have PTSD, anxiety disorders, OCD, and certain chronic pain conditions.

That said, whether ketamine therapy makes sense for a particular person depends on their full medical history. A licensed provider needs to evaluate that before any treatment starts.

IV ketamine is delivered through an intravenous line in a clinic setting and is used off-label for psychiatric and pain conditions. Spravato is an FDA-approved nasal spray form of esketamine that is self-administered in the clinic under supervision. The two differ in how they are delivered, how long a session takes, and how insurance typically responds to them.

A nurse or other clinician places an IV line and adjusts the dose over a session that typically lasts around 40 to 60 minutes. You stay in a monitored room throughout, and a provider tracks your blood pressure and heart rate. Most people experience perceptual changes during the session that resolve before you leave. You will need someone to drive you home afterward.

With Spravato, you administer the nasal spray yourself under clinical supervision, then remain at the clinic for a monitoring period of at least two hours. The session is longer than a typical infusion but does not require an IV line. Clinics are required to observe you on site for the full monitoring window before you are cleared to leave.

The largest concentration of clinics is in Denver and the surrounding suburbs, like Aurora, Centennial, Englewood, Greenwood Village, Lakewood, and Littleton. Colorado Springs is a strong secondary hub. Clinics also operate in Boulder, Fort Collins, Grand Junction, Durango, Loveland, and several mountain communities along the I-70 corridor.

Most IV ketamine infusions are paid for out of pocket because insurance plans do not typically cover them. Spravato is the treatment most likely to have some insurance coverage, since it is FDA-approved, but actual coverage depends heavily on your specific plan and diagnosis.

Always call your insurer before scheduling, and ask the clinic whether they help with prior authorization paperwork.

Several Colorado clinics publish their per-infusion rates, so you can find real numbers before calling. The total cost of a starter course depends on which format you choose and how many sessions it includes. A multi-session initial series costs substantially more than a single appointment, so ask for a full course estimate rather than just the per-visit price.

Yes. This directory only lists clinics that administer ketamine treatment on site. At-home or telehealth ketamine programs are not included.

Start by confirming that the clinic offers the specific treatment format your provider has recommended, since not every clinic in the state offers every format. Then ask about who oversees your care, what monitoring is done during sessions, and what the plan looks like after the initial course ends. Transparent pricing and a clear follow-up protocol are both good signs.

Yes. Ketamine is a Schedule III controlled substance under U.S. federal law and is legal for licensed clinicians to prescribe and administer off-label, including for treatment-resistant depression and other conditions. Spravato (esketamine), the FDA-approved nasal-spray form, is dispensed only in certified healthcare settings under a federal Risk Evaluation and Mitigation Strategy (REMS) program. That applies in Colorado as it does nationwide. The standards for who may administer treatment are set by state regulators and by the clinicians themselves; you can look up the current licensing board for your state through the Federation of State Medical Boards directory at fsmb.org. This page is informational and not legal or medical advice. Consult a licensed medical provider before starting treatment.