The California Neuropsychiatric Institute

The California Neuropsychiatric Institute offers Spravato esketamine treatment in Upland, California, for adults with treatment resistant depression. Taken as a nasal spray alongside an oral antidepressant, it can reduce symptoms within hours rather than weeks. Low dose ketamine has also been shown to rapidly reduce suicidal thoughts.

Upland is the practice's Inland Empire office and the original location. Patients here also have access to clinical trials run through the institute.

Treatment plans are built using neuropsychological testing, genetic testing, and biomarker testing rather than trial and error alone. The team follows a research based framework focused on brain circuits and combines biological, psychosocial, and cultural approaches. The clinic serves Upland, Ontario, Rancho Cucamonga, and Claremont.