Desert Health Clinic

Desert Health Clinic in Tucson, Arizona offers Spravato (esketamine), an FDA-approved nasal spray for adults with treatment-resistant depression or major depression with suicidal thoughts. It can be used on its own or alongside an oral antidepressant, and is administered in a safe, comfortable setting under medical supervision.

Esketamine works differently than traditional antidepressants, acting as an NMDA receptor antagonist that targets glutamate pathways in the brain. Some patients experience improvement within hours or days rather than weeks. Treatment typically begins with twice-weekly dosing for the first four weeks, then transitions to weekly or every-other-week maintenance based on response.

Because Spravato is part of the REMS program, blood pressure is monitored before and after each dose, and patients remain at the clinic for at least two hours afterward. Desert Health Clinic also offers TMS, ketamine therapy, and genetic testing as part of its mental health services.