Unchained Psychiatry & Wellness

Unchained Psychiatry & Wellness in Gilbert, Arizona is an interventional psychiatry practice offering IV ketamine infusions, Spravato (esketamine), and TMS for treatment-resistant depression, PTSD, severe anxiety, and chronic pain. IV ketamine is physician-supervised by the psychiatry-led team and delivered in a calm, monitored clinical setting.

Ketamine works through a different pathway than SSRIs and SNRIs, blocking NMDA receptors to trigger a glutamate surge that promotes new synaptic connections and neuroplasticity. This is why relief can come rapidly, often within hours of the first infusion. A standard induction course is six infusions over two to three weeks, each lasting about 1.5 to 2 hours, followed by maintenance as needed.

For patients who prefer an insurance-covered option, the practice is a REMS-certified Spravato provider, offering the FDA-approved nasal spray for treatment-resistant depression and suicidal ideation. Unchained also provides medication management and psychiatric IV therapy as part of its comprehensive approach.